High Resolution Diffusion Tensor Imaging of Cortical-Subcortical White Matter Tracts in TBI
Annual rept. 15 Sep 2008-14 Sep 2009
ILLINOIS UNIV AT CHICAGO
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The most significant finding to date is the identification of what potentially may prove to be a central mechanism of cognitive impairment following traumatic brain injury. Although data collection is on-going as is data analysis, we focused in year 1 on validating and implementing analysis of integrity of thalamic projection fibers in a subgroup of 12 controls and 24 patients with TBI. The data show that cortical damage, long thought to be the underlying mechanism of impairment, does not account for cognitive impairment. Instead, our data demonstrate a strong relationship between thalamic projection fibers and executive function. A version of the manuscript is included. The data has been presented at the military research health conference, society for neurotrauma, and will be presented at the upcoming society for neuroscience. The manuscript received positive reviews at the first submission to Neurology and a revision is presently undergoing peer review at that journal.
- Anatomy and Physiology
- Medicine and Medical Research