MicroRNAs in Tamoxifen Resistance of Breast Cancer
Annual rept. 15 Jul 2008-14 Jul 2009
H LEE MOFFITT CANCER CENTER AND RESEARCH INST TAMPA FL
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Three tasks have been proposed in this project 1 Examine the expression of the miRNAs identified from the microarray profiling in human primary ERalpha-positive-tamoxifen-responsive vs. ERalpha-positive TMR and ERalpha-negative TMR breast cancers as well as intrinsic ERalpha-negative tumors 2 Verify predictive targets of the miRNAs described above and 3 Restore tamoxifen sensitivity in TMR cells by knockdown or expression of the deregulated miRNAs in breast cancer cells.
- Medicine and Medical Research