Accession Number:

ADA512924

Title:

MicroRNAs in Tamoxifen Resistance of Breast Cancer

Descriptive Note:

Annual rept. 15 Jul 2008-14 Jul 2009

Corporate Author:

H LEE MOFFITT CANCER CENTER AND RESEARCH INST TAMPA FL

Personal Author(s):

Report Date:

2009-08-01

Pagination or Media Count:

30.0

Abstract:

Three tasks have been proposed in this project 1 Examine the expression of the miRNAs identified from the microarray profiling in human primary ERalpha-positive-tamoxifen-responsive vs. ERalpha-positive TMR and ERalpha-negative TMR breast cancers as well as intrinsic ERalpha-negative tumors 2 Verify predictive targets of the miRNAs described above and 3 Restore tamoxifen sensitivity in TMR cells by knockdown or expression of the deregulated miRNAs in breast cancer cells.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE