Neural Plasticity and Neurorehabilitation Following Traumatic Brain Injury
Annual rept. 15 Sep 2008-14 Sep 2009
DE PAUL UNIV CHICAGO IL
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Rehabilitation following traumatic brain injury is not well understood and has relied primarily on findings from studies conducted in stroke. We have demonstrated that following CCI a rodent model of contusion TBI, behavioral function was most enhanced by combining 3 types of forelimb rehabilitation tray reaching, exercise, and forelimb constraint. This enhancement was seen in tests of Forelimb Reaching but not Forelimb Coordination. Combining all three rehabilitation therapies also enhanced performance on rehabilitation tasks. CCI results in a drastic loss of movement representations in the motor cortex, an effect far more severe than expected based on stroke models. Despite this, the motor cortex near the contusion maintains the capacity for motor map plasticity.
- Anatomy and Physiology
- Medicine and Medical Research