Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure
Annual rept. 1 Jul 2008-30 Jun 2009
TEMPVA RESEARCH GROUP INC TEMPLE TX
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Although selective serotonin reuptake inhibitors SSRIs are routinely prescribed for acute stress disorder and early PTSD and recommended in the VA-DoD best practice guidelines, the efficacy of SSRIs as an early intervention for PTSD in service members returning from war-zone duty has still not been determined. Consequently, this study was designed to conduct a controlled trial of fluoxetine as an early intervention for recently redeployed soldiers, as well as to develop methodologies for understanding the multiple factors that may predict outcome. The Brooke Army Medical Center IRB, the regional IRB for the Carl R. Darnall Army Medical Center, has given full approval. A CRADA between TEMPVA Research Group, Inc and the Carl R. Darnall Army Medical Center has been executed. The protocol has now also been approved by the Central Texas Veterans Health Care System CTVHCS IRB and the Research and Development Committee. The review by Kristen R. Katopol, MS, CIM, Human Subjects Protection Scientist AMDEX Corp. Human Research Protection Office HRPO Office of Research Protections ORP U.S. Army Medical Research and Materiel Command USAMRMC Fort Detrick has been completed and the BAMC IRB is reviewing the documents revised to comply with her audit. No subjects have been enrolled and will not be enrolled until final approval is obtained from USAMRMC.
- Personnel Management and Labor Relations
- Medicine and Medical Research
- Stress Physiology