Molecular Genetic Studies of Bone Mechanical Strain and of Pedigrees with Very High Bone Density
Annual rept. 31 Oct 2008-30 Oct 2009
LOMA LINDA VETERANS ASSOCIATION FOR RESEARCH AND EDUCATION REDLANDS CA
Pagination or Media Count:
The primary goal of the proposed work is to identify the genes and their functions involved in mediating the anabolic response to mechanical stress. During the past year, we have used state-of-the-art technologies to investigate the role of a number of potential candidate genes in mediating skeletal anabolic response to mechanical loading. We found that modulation of leptin signaling influences mechanical loading response in the skeleton. We have also established using mice with conditional disruption of IGF-I in osteoblasts that local IGF-I expression in bone is essential for skeletal anabolic effects of exercise. On the other hand, disruption of formin- 2, a mechanoresponsive gene, did not influence skeletal anabolic response to mechanical loading. We believe that successful accomplishment of the proposed studies will provide a better understanding of the molecular mechanisms involved in identifying the genes and their function as related to mechanical stress.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research