Accession Number:

ADA512080

Title:

An Active Insect Kinin Analog with 4-Aminopyroglutamate, A Novel cis-Peptide Bond, Type VI beta-Turn Motif

Descriptive Note:

Journal article

Corporate Author:

SOUTHERN PLAINS AGRICULTURAL RESEARCH CENTER COLLEGE STATION TX AREAWIDE PEST MANAGEMENT RESEARCH UNIT

Report Date:

2004-01-01

Pagination or Media Count:

9.0

Abstract:

The insect kinins are potent diuretic peptides that preferentially form a cis-Pro, type VI beta-turn. An insect kinin analog containing 2S,4S-4-aminopyroglutamate, a novel cis-peptide bond, type VI beta-turn motif, demonstrates significant activity in the physiological range in a cricket diuretic assay. This is the first instance of a 4-aminopyroglutamate analog of a peptide with a preference for a type VI turn that demonstrates significant bioactivity. The results provide further confirmatory evidence for the active conformation of the insect kinins, and a new scaffold with which to design biostable, peptidomimetic analogs capable of disrupting critical insect kinin-regulated processes in insects.

Subject Categories:

  • Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE