Regulatory T Cells and Host Anti-CML Responses
Final rept. 1 Jun 2007-31 May 2009
CITY OF HOPE BECKMAN RESEARCH INST DUARTE CA
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CD4CD25FoxP-3 regulatory T-cells Tregs suppress immune responses to self antigens, but also have been shown to suppress host anti-tumor responses in several human malignancies, including breast, gastrointestinal, and ovarian cancer. Identification of CML Tregs as suppressors of host anti-CML responses could have a significant impact upon CML treatment strategies. Methods are currently available to selectively suppress Tregs and subsequently boost host anti-CML responses. We have examined the CD4CD25FoxP-3 regulatory T-cell population in the peripheral blood from healthy individuals and those with CML using flow cytometry. Our results demonstrate that subjects with CML who have detectable residual disease have a larger percentage of CD4s that are Tregs 6.89 - 3.32 vs 1.94 - 0.99, p 0.003and a 3.5 fold larger absolute number of circulating CD4CD25FoxP3 T-cells 1,743 - 1,350 vs 455 - 234, p0.02, consistent with our hypothesis. The larger numbers of circulating Tregs appears to correlate with CML disease activity. We are continuing to examine functional correlates of this CML Treg population.
- Medicine and Medical Research