Accession Number:

ADA510759

Title:

Regulatory T Cells and Host Anti-CML Responses

Descriptive Note:

Final rept. 1 Jun 2007-31 May 2009

Corporate Author:

CITY OF HOPE BECKMAN RESEARCH INST DUARTE CA

Personal Author(s):

Report Date:

2009-06-01

Pagination or Media Count:

9.0

Abstract:

CD4CD25FoxP-3 regulatory T-cells Tregs suppress immune responses to self antigens, but also have been shown to suppress host anti-tumor responses in several human malignancies, including breast, gastrointestinal, and ovarian cancer. Identification of CML Tregs as suppressors of host anti-CML responses could have a significant impact upon CML treatment strategies. Methods are currently available to selectively suppress Tregs and subsequently boost host anti-CML responses. We have examined the CD4CD25FoxP-3 regulatory T-cell population in the peripheral blood from healthy individuals and those with CML using flow cytometry. Our results demonstrate that subjects with CML who have detectable residual disease have a larger percentage of CD4s that are Tregs 6.89 - 3.32 vs 1.94 - 0.99, p 0.003and a 3.5 fold larger absolute number of circulating CD4CD25FoxP3 T-cells 1,743 - 1,350 vs 455 - 234, p0.02, consistent with our hypothesis. The larger numbers of circulating Tregs appears to correlate with CML disease activity. We are continuing to examine functional correlates of this CML Treg population.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE