The Mission Connect Mild TBI Translational Research Consortium
Annual rept. 1 Aug 2008-31 Jul 2009
TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
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In this study we propose to use magnetoencephalography MEG to detect and characterize focal abnormalities in neurophysiological function in patients with mTBI and PTSD for the purpose of distinguishing between the two. MEG is a completely non-invasive imaging modality which is able to provide information regarding focal abnormalities in the brain. MEG has been shown to be sensitive to cognitive complaints in patients with mTBI. In addition neurophysiological abnormalities differentiate patients with mTBI and PTSD in some studies. We also propose to explore the relationship between diffusion tensor imaging DTI and MEG findings. While MEG provides data regarding focal abnormalities in neural response in the cortex, DTI reveals the status of white matter tracts that form the intracortical connections. Thus, MEG, in combination with DTI, may lead to identification of more distinct, replicable patterns of brain abnormalities in subjects with PTSD and mTBI that may lead to better differentiation between these groups of patients, as well as from patients with a combination of both disorders. We continue to await approval to begin to collect data from patients at this time.
- Anatomy and Physiology
- Medicine and Medical Research