The Effect of Hypotensive Resuscitation and Fluid Type on Mortality, Bleeding, Coagulation and Dysfunctional Inflammation in a Swine Grade V Liver Injury Model
Annual rept. 8 Dec 2007-7 Dec 2008
OREGON HEALTH AND SCIENCE UNIV PORTLAND
Pagination or Media Count:
Objectives To determine the efficacy and safety of lyophilized plasma for the treatment of multisystem trauma in pigs. Methods 1. 32 swine at 2 institutions underwent femur fracture, controlled hemorrhage 30 estimated blood volume, hypothermia 33 deg C and resuscitation with normal saline and Grade V liver injury followed by 30 minutes of hemorrhagic shock without resuscitation. Animals were then randomized to Fresh Frozen Plasma FFP, Lyophilized Plasma LP, 11 PRBCFFP, and 11 PRBCLP. Animals were followed for four hours post liver injury. Physiologic parameters, coagulation assays and inflammatory mediators were compared. Results 1. There were no significant differences in any physiologic parameters Mean Arterial Pressure, Heart Rate, Mortality, or Blood Loss between the groups. Coagulation parameters did not differ between groups. Analysis of inflammatory markers showed significantly lower values for LP animals compared to FFP animals at 2 hours post injury. Conclusion LP is as safe and effective as FFP for resuscitation in a severe hemorrhagic shock model and it may reduce harmful inflammation associated with severe trauma.
- Medicine and Medical Research
- Physical Chemistry