Accession Number:

ADA510112

Title:

Development of Highly Sensitive Bulk Acoustic Wave Device Biosensor Arrays for Screening and Early Detection of Prostate Cancer

Descriptive Note:

Annual rept. 1 Jan 2007-31 Dec 2008

Corporate Author:

GEORGIA TECH RESEARCH CORP ATLANTA

Report Date:

2009-01-01

Pagination or Media Count:

269.0

Abstract:

In this research, I present several novel contributions to the field of microelectronic acoustic biosensors that approach the goal of developing a cost-effective, highly sensitive and highly selective sensor array for the detection of early cancer proliferation. First I report on the development of a novel solidly mounted shear-mode resonator employing piezoelectric ZnO as an appropriate base device for liquid-phase sensing applications. Second I report on the development of a novel and appropriate chemical surface preparation protocol for the covalent immobilization of monoclonal IgG antibodies to the surface of this device, thereby functionalizing it as a biosensor. Proof of functionality is demonstrated employing these sensors for the detection of various known cancer biomarkers in complex media as well as progress towards developing a packaged disposable sensor array system is also reported.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Medical Facilities, Equipment and Supplies
  • Acoustic Detection and Detectors

Distribution Statement:

APPROVED FOR PUBLIC RELEASE