Mission Connect Mild TBI Translational Research Consortium
Annual rept. 1 Aug 2008-31 Jul 2009
BAYLOR COLL OF MEDICINE HOUSTON TX
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This project addresses the treatment of deleterious oxy-radical production following traumatic brain injury using anti-oxidant nanomaterials. Our evidence indicates that traumatic brain injury generates superoxide radical rapidly and persistently, which is exacerbated by systemic hypotension and resuscitation. Conventional anti-oxidant therapy is either not sufficiently potent nor long lasting. Nanomaterials synthesized in our collaborators in the Tour laboratory demonstrated potent anti-oxidant activity in preliminary results. We have developed several assays in the Kent laboratory that measure relevant anti-oxidant activity to our in-vivo purposes, including total anti-oxidant activity and activity against the superoxide radical, as well as testing for interactions with the fluorescent techniques planned for use in-vivo as well as assays to determine toxicity.
- Weapons Effects (Biological)