Changes in Ovarian Stromal Function and Associated Symptoms in Premenopausal Women Undergoing Chemotherapy for Breast Cancer
Annual summary rept. 1 Aug 2003-31 Jul 2008
MAYO CLINIC ROCHESTER MN
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The objective of this pilot study was to identify if androgen levels are adversely affected by adjuvant chemotherapy for breast cancer and whether low androgen levels are correlated with the frequency and severity of fatigue, weight gain, psychological symptoms, vasomotor symptoms and libido. A longitudinal, descriptive design was used with questionnaires completed and blood drawn from 20 premenopausal women at 4 time periods before treatment, mid-treatment, immediate post-treatment and 6 months later. Questionnaires included the Female Sexual Function Index, Greeene Climacteric Scale, Profile of Mood States, Schwartz Fatigue Scale and a menses diary. Data analysis involved descriptive statistics, plots of hormone levels over time, t-tests to examine changes in hormone levels, and correlational analysis to determine relationships between hormone levels and symptoms. Preliminary data indicate that women 40 stopped menstruating, had FSH levels 40 IUl and androgen function decreased by at least 35. Women 40 retained ovarian function. Sexual function, vasomotor symptoms, vigor and fatigue became progressively worse through treatment. These data provide evidence that chemotherapy impacts androgens.
- Anatomy and Physiology
- Medicine and Medical Research