New Bone Foundation in a Chronically-Infected Segmental Defect in the Rat Femur Treatment with BMP-2 and Local Antibiotic
Annual rept. 1 Feb-31 Dec 2007
MINNESOTA UNIV MINNEAPOLIS
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The majority of the combat casualties that occur in Operations Iraqi Freedom and Enduring Freedom are a result of high-energy blast or high-velocity projectile mechanisms, and commonly present with a significant segmental bone defect, massive soft tissue disruption and loss, and substantial contamination with bacteria. The goal of this research was to improve the treatment of infected segmental bone loss by using currently available off-the-shelf biologics and antibiotics. Specifically, the aim of this study was to determine whether recombinant human bone morphogenetic protein-2 rhBMP-2 and antibiotic delivered locally from a composite carrier, in combination with a second antibiotic delivered systemically, could lead to new bone formation in an internally-stabilized rat femoral segmental defect with a chronic infection from Staphylococcus aureus. It is hypothesized that i chronically-infected defects treated with debridement and rhBMP-2 would form significantly more and stronger new bone than debrided defects without rhBMP-2, ii defects treated with debridement, rhBMP-2 and local administration of a high dose of antibiotic would form significantly more and stronger new bone than debrided defects treated with rhBMP-2 alone, and iii defects treated with debridement, rhBMP-2, local administration of a high dose of antibiotic, and systemic administration of a second antibiotic, would form significantly more and stronger new bone than debrided defects treated with rhBMP-2 and local antibiotic alone.
- Medicine and Medical Research