Contribution of AMACR and Phytanic Acid to Prostate Cancer Risk Among African Americans in North Carolina
Final rept. 15 Jan 2006-14 Apr 2009
WAKE FOREST UNIV WINSTON-SALEM NC SCHOOL OF HEALTH SCIENCES
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Several lines of evidence have suggested genetic and dietary differences may be important in PCa, particularly among AA African American men. In this study, we aimed to test the hypothesis that mutationssequence variants in the AMACR gene, and dietary intake of foods rich in phytanic acid, increase the risk to PCa among AA men. We conducted a population based study by ascertaining 213 AA men who have PCa and 264 race, age, and county-matched controls from 15 counties of North Carolina. We have completed the 1st task, study subject recruitment. We have also obtained additional grant funding related to the science of this project, which will help provide independent confirmation of the findings from this study in a different study population. We have used the newly recruited study population to complete a study confirming genome-wide variants in AA PCa cases and controls, and our results are in-press. The results from this project have increased our knowledge of potential risk factors and suggest potential preventive strategies for prostate cancer in AA men.
- Medicine and Medical Research