Natural History of Plexiform Neurofibromas in NF1. Addendum
Final rept. 1 Oct 1998-30 Sep 2008
ALABAMA UNIV IN BIRMINGHAM
Pagination or Media Count:
The overall goal of this study was to use volumetric MRI to define the natural history of untreated plexiform neurofibromas in patients with NF1. MRIs were obtained from patients with untreated plexiform neurofibromas and sent to a central location for volumetric analysis. Following the initial analysis using a manual method to delineate tumor boundaries, data were reanalyzed using two separate approaches to semi-automated analysis. Overall, most tumors, regardless of body site, remained stable in size during the course of study. There was a trend towards more rapid growth in younger patients, however. In addition, the imaging characteristics of superficial and abdominal plexiform neurofibromas have been described. The results have demonstrated that volumetric MRI provides a reproducible and practical approach to measurement of the growth of plexiform neurofibromas. This approach is now the standard approach in use to measure response of plexiform neurofibromas to therapy, including in the clinical trials being conducted by the NF Consortium.
- Anatomy and Physiology
- Medicine and Medical Research