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Transrectal Near-Infrared Optical Tomography for Prostate Imaging

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Annual rept. 1 Mar 2008-28 Feb 2009

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The objective of this research is to explore the technology of trans-rectal near-infrared NIR optical tomography for accurate, selective prostate biopsy. Prostate cancer is the most common non-dermatologic cancer in American men. Prostate cancer suspicion is typically based on an elevated serum prostate-specific antigen PSA level or a suspicious nodule found during a digital rectal exam DRE. When the PSA level is elevated or the DRE shows abnormal, there is a 25 chance that cancer is present. The existence of prostate cancer can only be confirmed by a needle biopsy that is guided by trans-rectal ultrasound TRUS. Since there are no pathognomonic findings for prostate cancer on ultrasound imaging, biopsies are taken following a systematic pattern throughout the prostate with preference given to the peripheral zone wherein most cancer are found. The accuracy of biopsy is questionable and many men undergo multiple biopsies due to the lack of a more specificsensitive imaging modality. Pathologic studies have demonstrated positive correlation between increased micro-vessel density and the onset of the disease. Near-infrared NIR optical tomography is known of sensitive to blood based contrast, therefore trans-rectally implemented NIR optical tomography may provide a new way of assessing the prostate cancer. One of the outcomes of trans-rectal NIR tomography of the prostate would be a more accurate imaging guidance for targeted prostate biopsy.

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  • Medicine and Medical Research

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