Accession Number:

ADA509759

Title:

Regulation of the Inflammasome, a Modulator of Caspase-1 Mediated Cytokine Production

Descriptive Note:

Annual summary rept. 1 Jul 2006-30 Jun 2009

Corporate Author:

PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s):

Report Date:

2009-07-01

Pagination or Media Count:

20.0

Abstract:

Aberrant regulation of the epidermal growth factor receptor is implicated in a number of epithelial cancers, including a large fraction of breast cancers. Antibody based inhibitors directed against the extracellular ligand binding domain of the receptor have proven to be a clinically viable cancer therapeutic. We have used mutagenesis and binding competition studies to map the epitopes of two inhibitory antibodies. Additionally, we have structurally and biochemically characterized a set of inhibitory single-domain VHH antibody fragments directed against the exctracellular domain of the receptor.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE