Regulation of the Inflammasome, a Modulator of Caspase-1 Mediated Cytokine Production
Annual summary rept. 1 Jul 2006-30 Jun 2009
PENNSYLVANIA UNIV PHILADELPHIA
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Aberrant regulation of the epidermal growth factor receptor is implicated in a number of epithelial cancers, including a large fraction of breast cancers. Antibody based inhibitors directed against the extracellular ligand binding domain of the receptor have proven to be a clinically viable cancer therapeutic. We have used mutagenesis and binding competition studies to map the epitopes of two inhibitory antibodies. Additionally, we have structurally and biochemically characterized a set of inhibitory single-domain VHH antibody fragments directed against the exctracellular domain of the receptor.
- Medicine and Medical Research