Requirements for the Development of Bacillus Anthracis Spore Reference Materials Used to Test Detection Systems
NATIONAL INST OF STANDARDS AND TECHNOLOGY GAITHERSBURG MD CHEMICAL SCIENCE AND TECHNOLOGY LAB
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Bacillus anthracis spores have been used as biological weapons and the possibility of their further use requires surveillance systems that can accurately and reliably detect their presence in the environment. These systems must collect samples from a variety of matrices, process the samples, and detect the spores. The processing of the sample may include removal of inhibitors, concentration of the target, and extraction of the target in a form suitable for detection. Suitable reference materials will allow the testing of each of these steps to determine the sensitivity and specificity of the detection systems. The development of uniform and well-characterized reference materials will allow the comparison of different devices and technologies as well as assure the continued performance of detections. This paper discusses the special requirements of reference materials for Bacillus anthracis spores that could be used for testing detection systems.
- Chemical, Biological and Radiological Warfare