Onboard SPECT for Localizing Functional and Molecular Targets in Metastatic Breast Cancer
Annual summary rept. 1 Jul 2008-30 Jun 2009
DUKE UNIV DURHAM NC
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The overall goal of this work is to assess the feasibility of using single photon emission computed tomography SPECT for imaging inside radiation therapy treatment rooms to localize functional molecular targets associated with metastatic breast cancer. A computer simulation was performed using a female NCAT phantom that had various tumor diameters and uptake ratios located in bone, chest wall and lung. SPECT scans were simulated for an anterior half-circular orbit that avoided the flat-top treatment couch. Image ensembles were generated for scan times of 4, 8 and 10 minutes. Localization of tumor centroids was assessed using nonprewhitening numerical observers. Localization was strongly dependent on tumor location relative to the detector trajectory, thus suggesting the need for custom detector trajectories. Certain results were encouraging. Localization accuracy was within 2 mm for 1.44- and 2.16-cm anterior tumors with 61 uptake ratios using 4 minute scans. Future work includes hardware studies to validate these results.
- Medicine and Medical Research