Advanced MRI in Blast-Related TBI
Annual rept. 1 Sep 2008-1 Aug 2009
WASHINGTON UNIV ST LOUIS MO
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The purpose of the research effort is to test two advanced MRI methods, DTI and resting-state fMRI, in active-duty military blast-related TBI patients acutely after injury and correlate findings with TBI-related clinical outcomes 6-12 months later. These methods may add clinically useful predictive information following traumatic brain injury that could be of assistance in standardizing diagnostic criteria for TBI, making return-to-duty triage decisions, guiding post-injury rehabilitation, and developing novel therapeutics. The overarching hypothesis guiding this project is that traumatic axonal injury is a principal cause of impaired brain function following blast-related TBI. The major findings as of 1 Aug 2009 are as follows 1 All required human studiesIRBHRPO approvals have been obtained. 2 A total of 63 subjects have been enrolled at Landstuhl Regional Medical Center, including 43 blast-related TBI patients and 20 controls. All acute MRI scans have been performed successfully with no adverse events. 3 Initial analyses of initial scans have revealed abnormalities on DTI indicative of traumatic axonal injury in 2043 injured subjects that were not detectible on conventional MRI or CT. 4 To date, 4 clinical outcome evaluations and repeat scans have been performed at Washington University with no adverse events.
- Medicine and Medical Research