A Blast Model of Traumatic Brain Injury in Swine
Annual rept. 15 Apr 2008-14 Apr 2009
NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO
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Although blast-induced traumatic brain injury BI-TBI is a significant cause of morbidity and behavioral dysfunction in warfighters returning from Iraq, laboratory models are not currently available to study the mechanisms underlying this critical injury and develop new therapies to treat survivors. Many TBI models are performed in rodents, and data from these models have been used as a basis for several disappointing Phase III clinical trials in humans with TBI. The failure of these trials may, in part, be due to differences between the rodent and human or pig brain. The development of a large-animal model of BI-TBI will revolutionize the study of this pressing clinical problem and rapidly facilitate the development of novel therapies to treat injured military personnel. Therefore, the purpose of the experiments proposed is to develop a survival model of BI-TBI in swine.
- Anatomy and Physiology
- Medicine and Medical Research