Development of Highly Sensitive Bulk Acoustic Wave Device Biosensor Arrays for Screening and Early Detection of Prostate Cancer
Annual summary 1 Jan 2007-31 Dec 2007
GEORGIA TECH RESEARCH CORP ATLANTA
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In this research, we present several novel contributions to the field of microelectronic acoustic biosensors that approach the goal of developing a cost-effective, highly sensitive and highly selective sensor array for the detection of early cancer proliferation. First we report on the development of a novel solidly mounted shear-mode resonator employing piezoelectric ZnO as an appropriate base device for liquid-phase sensing applications. Second we report on the development of an appropriate chemical surface preparation protocol for the covalent immobilization of monoclonal IgG antibodies to the surface of this device, thereby functionalizing it as a biosensor. Preliminary data employing these sensors for the detection of prostate specific antigen in LnCap conditioned medium as well as progress towards developing a packaged disposable sensor array system is also reported. This research has thus far yielded three journal publications and three conference abstracts, which are provided in the report.
- Anatomy and Physiology
- Medicine and Medical Research