Microtubule-Associated Protein Expression and Predicting Taxane Response
Annual summary rept. 15 Sep 2007-14 Sep 2008
YALE UNIV NEW HAVEN CT
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We hypothesized that in addition to its predictive value, the microtubule-associated marker tau MAP-tau may also function as a prognostic biomarker. The dual functionality of MAP-tau may translate into increased tumor molecular screening information for patients with breast cancer resulting in better treatment options. Previous results of this work indicate that MAP-tau functions as a prognostic marker in early stage breast cancer when examined using tissue microarrays and automated quantitative analysis AQUA. Current work corroborates these results in the metastatic setting as well using tissue whole sections from the TAX 307 clinical trial . This work demonstrates that increased MAP-tau expression in both early and metastatic settings is associated with better outcome and increased time to tumor progression, respectively. Our findings suggest that MAP-tau is a useful prognostic marker but is not predictive of taxane response. Future work will examine MAPtau in combination with destabilizing MAPs such as stathmin which may provide a more robust model for taxane responsiveness.
- Anatomy and Physiology
- Medicine and Medical Research