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A Pyrophosphate Based Energy Generating Module
TEXAS UNIV AT SAN ANTONIO
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The most widely used transient form of stored energy in biological systems is the complex, organic molecule, adenosine triphosphate ATP. However, the much smaller, simpler pyrophosphate PPi molecule could potentially serve as an inexpensive, high energy bond, ATP mimic. Pyruvate Phosphate Dikinase PPDK, an enzyme found primarily in a small number of primitive protists reversibly transfers phosphate Pi from phosphoenolpyruvate PEP and PPi to AMP producing ATP. Alpha-Hemolysin pore-functionalized, lipid bilayers facilitated movement of PEP and PPi through 1-2 nm pores with concomitant Luciferase coupled ATP dependent generation of light. This is an important first step towards developing self-renewing power for nanomicro systems.
APPROVED FOR PUBLIC RELEASE