Accession Number:

ADA505738

Title:

Genome to Phenome: Integromic Approaches to Define Networks of Host-Pathogen Interactions and Vaccine Biomarker Discovery

Descriptive Note:

Conference rept.

Corporate Author:

WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD

Personal Author(s):

• Hammamieh, Rasha
• Jett, Marti

Report Date:

2008-12-01

Pagination or Media Count:

7.0

Abstract:

The rapid development of genomics, proteomics and high-throughput computing approaches to study diseases is now allowing us to apply an integrative systems biology work frame for drug and biomarker development. Understanding the symbiosis of pathogen and host at the molecular level requires a comprehension of the molecularcellular events by which the pathogens can induce alterations in the host in order to invade, proliferate and overtake the host. Our research focuses on defining the molecular eventsnetwork systems involved in the host-pathogen interactions to identify biomarkers and therapeutic targets for pathogenic agents.

Descriptors:

• *PATHOGENIC MICROORGANISMS
• *HOSTS(BIOLOGY)
• *VACCINES
• *GENOME
• CELLS(BIOLOGY)
• COMPREHENSION
• TRACER STUDIES
• GENES
• MOLECULAR STRUCTURE
• THERAPY
• NETWORKS

Subject Categories:

• Medicine and Medical Research
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE