Accession Number:

ADA505309

Title:

Regulation and Action of SKP2 in Cell and Tumor Models: Mechanisms Underlying Aggressive Growth in Basel-Like Breast Cancer

Descriptive Note:

Annual summary rept. 15 May 2008-14 May 2009

Corporate Author:

MASSACHUSETTS UNIV AMHERST

Personal Author(s):

• Fagan-Solis, Katerina

Report Date:

2009-06-01

Pagination or Media Count:

6.0

Abstract:

The objective of this research is to further our understanding of the molecular mechanisms underlying the aggressive growth of estrogen receptor ER-negative, basal-like breast tumors. My goal is to determine if SKP2 is a viable new therapeutic target to specifically treat patients who have tumors that are independent of ER signaling. The most significant finding during this research period is that SKP2 protein was expressed in 60 21 of 35 of ER-negative tumors, 25 26 of 104 of ER-positive tumors, and 10 5 of 50 reductive mammoplasty tissues. These data suggest that SKP2 overexpression is a phenomenon associated with ER-negative tumors. With an additional 150-300 ER-negative tumor cases this relationship will be better elucidated.

Descriptors:

• *BREAST CANCER
• NEOPLASMS
• THERAPY
• RECEPTOR SITES(PHYSIOLOGY)
• ESTROGENS
• PHOSPHORUS TRANSFERASES
• PROTEINS
• MOLECULAR PROPERTIES

Subject Categories:

• Biochemistry
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE