Accession Number:

ADA505267

Title:

Role of Hsp90 in Androgen-Refractory Prostate Cancer

Descriptive Note:

Annual rept. 1 Mar 2008-28 Feb 2009

Corporate Author:

PITTSBURGH UNIV PA

Personal Author(s):

• Wang, Zhou

Report Date:

2009-03-01

Pagination or Media Count:

13.0

Abstract:

A major challenge in prostate cancer research is to develop novel therapies that can delay or prevent the progression of androgen-sensitive prostate cancer to androgen-independence. Androgen receptor AR is often overexpressed and plays an essential role in androgenrefractory prostate tumors. Our preliminary studies suggest that heat shock protein 90 Hsp90 is required for androgen-independent AR nuclear localization in androgen-refractory prostate cancer cells. This project will test our research hypothesis that Hsp90 plays a critical role in ligand-independent AR nuclear localization, an essential step leading to androgen-refractory prostate cancer. In the last year of the funding period, we showed that Hsp90 deacetylation by HDAC6 is a critical step involved in castration resistance of prostate cancer cells.

Descriptors:

• *PROSTATE CANCER
• NEOPLASMS
• HYPOTHESES
• MEDICAL RESEARCH
• CELLS(BIOLOGY)
• EXCISION
• PROSTATE GLAND
• TESTES
• ANDROGENS
• RESISTANCE
• SENSE ORGANS

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE