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Improved Therapeutic Regimens for Treatment of Post-Traumatic Ocular Infections
Annual rept. 15 Apr 2008-14 Apr 2009
OKLAHOMA UNIV HEALTH SCIENCES CENTER OKLAHOMA CITY
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Greater than 10 of battlefield injuries occur to the eyes, resulting in significant morbidity. The potential for ocular infection by trauma is high, due to the types of organisms encountered in arid environments and the delay between injury and adequate treatment. This proposal was designed to analyze the effectiveness of antibiotics, antiinflammatory drugs, and non-conventional agents targeting bacterial and host virulence factors, with the goal of improving the outcome of infections that would otherwise result in vision loss. The 2nd-year results highlight prompt and aggressive intravitreal therapy in preventing inflammation and vision loss. Delays in treatment result in vision loss, but may not result in loss of the eye, a cosmetic benefit. Our testing of additional antiinflammatory agents with antibiotics did little to clarify whether these drugs are of any benefit during therapy. The use of vitrectomy to clear intraocular inflammation and damaged tissue may not be of much therapeutic benefit as well. With the first 2 years of study taken together, we have provided new information on improvements in treatment regimens that preserve vision and ocular architecture. Further analysis of non-conventional therapies will identify those that may be implemented for future treatment of blinding bacterial infections of the eye.
APPROVED FOR PUBLIC RELEASE