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Immunology, Systems Biology, and Immunotherapy of Breast Cancer

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Annual rept. 1 Mar 2008-28 Feb 2009

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In year 3, we built upon the foundation from the first two years of this award, and are making progress in multiple areas of this project. We now have an efficient system in place to recruit patients into this study and procure their samples. Limited numbers of subjects available and limited amounts of clinical materials available from each subject remain major challenges to the success of this project - we continually attempt to address and solve this issue by reducing the cell numbers that we need for each assay. We have developed a powerful set of immunological assays and molecular tools to study these samples in greater detail than previously possible. We continue to uncover dramatic changes in the immune cell populations within tumors, TDLNs, and peripheral blood from breast cancer patients. These findings are reported above, and have led to 3 manuscripts under review. We look forward in the coming year to build upon this momentum and specifically to elucidate insights into the immunobiology of breast cancer. In the coming year and beyond, we will begin to focus on translating our early findings into novel therapeutic strategies for the immunotherapy of breast cancer.

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  • Medicine and Medical Research

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