Accession Number:

ADA505160

Title:

Dual-Modality Prostate Imaging with PET and Transrectal Ultrasound

Descriptive Note:

Annual rept.

Corporate Author:

CALIFORNIA UNIV BERKELEY LAWRENCE BERKELEY LAB

Personal Author(s):

• Huber, Jennifer S.

Report Date:

2009-04-01

Pagination or Media Count:

75.0

Abstract:

We developed the hardware and software tools needed for dual Positron Emission Tomography-Transrectal Ultrasound PET-TRUS imaging of the prostate. We acquired and modified the necessary TRUS equipment to work when mounted on a patient table in conjunction with the prostate-optimized PET scanner or the EXACT HR PET scanner. We developed software to determine the location of two point sources and calculate the corresponding location of the TRUS probe tip both in PET coordinates, reconstruct PET data, reslice PET imaging data sets into TRUS coordinates, and display fused PET-TRUS images. We validated methods for positioning a patients prostate in the center of the PET scanner with 1 mm accuracy. We also constructed and imaged one-of-a-kind PET-TRUS prostate phantoms, using these phantoms to evaluate our dual PET-TRUS imaging techniques. We estimate our PET-TRUS image co-registration error to be 2 mm based on this preliminary phantom imaging, but we will perform further validation in Year 3 using a newly designed PET-TRUS phantom. Finally, we have updated IRB approval for patient studies.

Descriptors:

• *IMAGES
• *PROSTATE GLAND
• DATA BASES
• VALIDATION
• SOFTWARE TOOLS
• PATIENTS
• DUAL MODE
• COMPUTER PROGRAMS
• SCANNING

Subject Categories:

• Anatomy and Physiology
• Machinery and Tools
• Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE