Accession Number:

ADA504652

Title:

Role of IRS1 and IRS2 in Modulating ErbB-induced Tumorigenesis

Descriptive Note:

Annual summary rept. 14 Apr 2008-13 Apr 2009

Corporate Author:

BAYLOR COLL OF MEDICINE HOUSTON TX

Personal Author(s):

Report Date:

2009-05-01

Pagination or Media Count:

17.0

Abstract:

Insulin receptor substrates 1 and 2 IRSs are adapter proteins which are required for the transforming ability of many oncogenes. Up to date, little is known about the interaction between IRSs and ErbB2 in epidermal growth factor receptor ErbB2Her2Neu amplified breast cancer. In a mouse study we found that overexpression of IRS2 had no effect upon ErbB2 induced mammary tumorigenesis in vivo. Whole mounts and hematoxylin and eosin HE analysis revealed no major morphological differences in ductal branching and tumor typesolid adenocarcinomas between ErbB2 and bigenic ErbB2IRS2 overexpressing mice. Furthermore, the metastatic potential of ErbB2 is not changed by additional overexpression of IRS2.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE