Role of IRS1 and IRS2 in Modulating ErbB-induced Tumorigenesis
Annual summary rept. 14 Apr 2008-13 Apr 2009
BAYLOR COLL OF MEDICINE HOUSTON TX
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Insulin receptor substrates 1 and 2 IRSs are adapter proteins which are required for the transforming ability of many oncogenes. Up to date, little is known about the interaction between IRSs and ErbB2 in epidermal growth factor receptor ErbB2Her2Neu amplified breast cancer. In a mouse study we found that overexpression of IRS2 had no effect upon ErbB2 induced mammary tumorigenesis in vivo. Whole mounts and hematoxylin and eosin HE analysis revealed no major morphological differences in ductal branching and tumor typesolid adenocarcinomas between ErbB2 and bigenic ErbB2IRS2 overexpressing mice. Furthermore, the metastatic potential of ErbB2 is not changed by additional overexpression of IRS2.
- Medicine and Medical Research