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Accurate and Fast Localization of Prostate for External Beam Radiation Therapy

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Annual summary 15 Feb 2008-14 Feb 2009

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The development of intensity modulated radiation therapy IMRT makes it possible to deliver high precision conformal dose distributions to the target. However, the non-rigid internal motion of the prostate makes it difficult to locate the target precisely during IMRT. In this project, we propose to develop a tomosynthesis-based method for fast and accurate prostate localization during IMRT. The hypothesis of this proposal is that the effective use of 3D information provided by tomosynthesis and the development of a non-rigid tomosynthesisCT registration technique will enable us to significantly improve the precision of prostate target localization. We have carried a systematic study on the tomosynthesis based prostate localization technique. A number of important milestones have been accomplished, which include i implemented a ray-tracing based projector to generate projection data from a digital phantom and analytical FDK image reconstruction algorithm to reconstruct tomosynthesis image ii Developed a statistics -based sinogram smoothing algorithm to suppress noise in projection data and improve image quality in reconstructed image and iii Developed an iterative image reconstruction algorithm with a new prior constraint to improve image quality and resolution in tomographic images. It is expected that these tools will improve the accuracy of the prostate localization for EBRT.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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