CHD8, A Novel Beta-Catenin Associated Chromatin Remodeling Enzyme, Regulates Androgen Receptor Mediated Gene Transcription
Annual rept. 1 Mar 2008-28 Feb 2009
MICHIGAN UNIV ANN ARBOR
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The activity of the androgen receptor AR is critical for normal prostate development and function, but AR activity also plays a major role in the development and progression of prostate cancer. To better understand the function of beta-catenin in AR mediated transcription, we have identified a novel chromatin remodeling enzyme, CHD8, that can associate with beta-catenin and functions in AR mediated gene transcription. Year 2 was focused on the continuing the first specific aim of this proposal the interaction of CHD8 with beta-catenin and the androgen receptor and starting the second specific aim the function of CHD8 and beta-catenin at the PSA promoter. This work is required for the study of the function of CHD8 and beta-catenin in AR mediated transcription and the ultimate understanding of the role played by CHD8 in prostate cancer progression.
- Anatomy and Physiology
- Medicine and Medical Research