Accession Number:

ADA504104

Title:

CHD8, A Novel Beta-Catenin Associated Chromatin Remodeling Enzyme, Regulates Androgen Receptor Mediated Gene Transcription

Descriptive Note:

Annual rept. 1 Mar 2008-28 Feb 2009

Corporate Author:

MICHIGAN UNIV ANN ARBOR

Personal Author(s):

Report Date:

2009-03-31

Pagination or Media Count:

8.0

Abstract:

The activity of the androgen receptor AR is critical for normal prostate development and function, but AR activity also plays a major role in the development and progression of prostate cancer. To better understand the function of beta-catenin in AR mediated transcription, we have identified a novel chromatin remodeling enzyme, CHD8, that can associate with beta-catenin and functions in AR mediated gene transcription. Year 2 was focused on the continuing the first specific aim of this proposal the interaction of CHD8 with beta-catenin and the androgen receptor and starting the second specific aim the function of CHD8 and beta-catenin at the PSA promoter. This work is required for the study of the function of CHD8 and beta-catenin in AR mediated transcription and the ultimate understanding of the role played by CHD8 in prostate cancer progression.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE