PSA-Based Screening Outcomes, Dietary Heterocyclic Amine Exposure, and Prostate Cancer Risk in African Americans
Final rept. 1 Jan 2005-31 May 2008
LAWRENCE LIVERMORE NATIONAL LAB CA
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Prostate cancer PC is the second leading cause of male U.S. cancer deaths, with African-Americans having the highest rate of PC mortality worldwide, as well as more abnormal results from screening tests that correlate with current or eventual PC. A 5-year prospective NIH-funded clinic-based study investigated whether prostate-specific antigen PSA and digital rectal exam DRE screening indicators of PC risk in 500 African-American men 50 to 70 years of age who underwent PC screening in Oakland, CA East Bay San Francisco area, were associated with estimated dietary exposures to 2-amino-1-methyl-6-phenylimidazo4,5-bpyridine PhIP, which forms when meat is overcooked. The DOD-funded study expands that NIH-funded work by adding a new -free-PSA test for 310 108 from the NIH-funded study, plus 202 additional men, results of which will be compared with PSA DRE results and PhIP exposures estimated by dietary interviews. For 392 men studied under the NIH protocol, an odds ratio 95 CL of 32 3.2, 720 for highly elevated PSA 20 ngmL was observed in the highest 15 vs. the lower 50 of estimated daily PhIP intakes. As of 09-01-07, a total of 310 men completed participation using the expanded protocol, for a combined total of 702 men. For the final analysis of all 702 men, the corresponding OR was found to be 10 2.9, 58. This study will help define the potential value of improved screening and dietarybehavioral intervention to reduce PC risk.
- Medicine and Medical Research
- Stress Physiology