Exploiting a Molecular Gleason Grade for Prostate Cancer Therapy
Annual rept. 15 Feb 2008-14 Feb 2009
FRED HUTCHINSON CANCER RESEARCH CENTER SEATTLE WA
Pagination or Media Count:
The Purpose of this proposal is to exploit a molecular correlate of the Gleason grading system for prostate carcinoma in order to a develop improved outcome predictors and b identify therapeutic strategies. During this project period we have evaluated in excess of 25 prostate cancer antigens by Western blot and tissue-based assays and identified 3 with detectable levels in the plasma. We also determined that developmental genes involved with invasive cellular behavior exhibit associations with clinical outcomes. While these results are important, the further exploitation of these findings is limited by the lack of specific antibodies suitable for tissue IHC and ELISA-based studies of protein localization and quantitation. Ongoing studies are focused on developing alternative strategies for protein quantitation in order to complete the proposal objectives.
- Medicine and Medical Research