Accession Number:

ADA503099

Title:

Free Energy Gap and Statistical Thermodynamic Fidelity of DNA Codes

Descriptive Note:

Journal article Postprint

Corporate Author:

MACULA (ANTHONY J) GENESSEO NY

Report Date:

2007-10-01

Pagination or Media Count:

18.0

Abstract:

DNA nanotechnology often requires collections of oligonucleotides called DNA free energy gap codes that do not produce erroneous cross hybridizations in a competitive multiplexing environment. This paper addresses the question of how to design these codes to accomplish a desired amount of work within an acceptable error rate. Using a statistical thermodynamic and probabilistic model of DNA code fidelity and mathematical random coding theory methods, theoretical lower bounds on the size of DNA codes are given. More importantly, DNA code design parameters e.g., strand number, strand length and sequence composition needed to achieve experimental goals are identified.

Subject Categories:

  • Computer Programming and Software
  • Solid State Physics
  • Thermodynamics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE