Effects of Radiation on Proteasome Function in Prostate Cancer Cells
Annual summary rept. 15 Jan 2008-14 Jan 2009
CALIFORNIA UNIV LOS ANGELES
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The proposed research is based on our observation that the 26S proteasome is a direct target of radiation. We initially planned experiments to investigate the association and release of PIPs from the 26S proteasome as well as studies more focused on the structural changes of the proteasome in response to radiation. We also wanted to investigate how the 26S is regulated by radiation at the transcriptional and posttranslational level and we are addressing these aims using powerful proteomic tools.
- Anatomy and Physiology
- Medicine and Medical Research