Prediction of Aggressive Human Prostate Cancer by Cathepsin B
MINNESOTA UNIV MINNEAPOLIS
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I received approval of the DOD-HSRRB in April, 2005 and began the study shortly after receiving approval. We are enclosing copies of published and accepted papers in the Anticancer Research. These papers address parts of both Specific Aims outlined in the project. I submitted an abstract of our accepted paper, Cathepsin B Expression Indicates that Prostate Cancer is Similar in African-American and Caucasian Men to the Department of Defense Prostate cancer research program meeting Innovative Minds in Prostate Cancer Today IMPACT. Our abstract was selected and accepted for presentation on September 5-6 meetings in Atlanta, GA. This is significant achievement for our work that started in April 2005. Our paper, Heterogeneity of Cathepsin B and Stefin A Expression in Gleason Pattern 33 score 6 Prostate Cancer Needle Biopsies was published in Anticancer Research 27 1407-1414, 2007. We showed that small foci of Gleason pattern 33 histological score 6 tumors in needle biopsies have heterogeneous cathepsin B and stefin A immunostaining. We have shown that score 6 tumors are heterogeneous and some of the tumors had micrometastases. We have suggested that stratification of these tumors by cathepsin B and stefin A in relation to clinical data may assist in identification of aggressive cancer and treatment selection.
- Anatomy and Physiology
- Medicine and Medical Research