Determination of Optimum Vitamin D Nutrition in Young Women
Annual rept. 30 Sep 2007-29 Sep 2008
CREIGHTON UNIV OMAHA NE
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The main objective of the current proposal is to study the effect of increasing doses of vitamin D3 in a group of young women with hypovitaminosis D serum 25OHD 20 ngml and an adequate calcium intake of 1200 -1400mgday. This is a double blind randomized placebo controlled study .There will be 5 treatment arms, four vitamin D3 dose groups ,400, 800, 1600, and 2400 IUday and placebo .Calcium citrate tablets will be given to maintain the calcium intake between 1200-1400mgd in all subjects. The study will recruit up to 100 Caucasian and 100 African American women subjects between age 25 and 45. The primary outcomes are changes in serum 25OHD and serum PTH. Secondary outcomes are calcium absorption, physical performance tests and safety measurements of serum calcium and 24 hour urine calcium. Subjects will be recruited in the spring and winter seasons of two consecutive years. In the first winter active recruitment started on April 1 2008 and finished in July 2008 and the first subject was randomized to treatment on 04282008. To date we have 49 subjects randomized to treatment 20 African Americans and 29 Caucasians.
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