Accession Number:

ADA499570

Title:

Killing Breast Cancer Cells through Activation of the Apoptosome

Descriptive Note:

Annual rept. 8 May 2007-7 May 2008

Corporate Author:

DUKE UNIV DURHAM NC

Personal Author(s):

Report Date:

2008-06-01

Pagination or Media Count:

7.0

Abstract:

Cells die in response to chemotherapeutic agents by activating a mitochondrial cell death pathway. This pathway leads to activation of proteases known as caspases through the release of cytochrome c from mitochondria. Once released, cytochrome c engages a cytoplasmic receptor known as Apaf-1, which oligomerizes and activates caspase 9. We demonstrated that breast cancer cells have apoptosomes which are hypersensitive to cytochrome c. Thus we have proposed to develop cytoplasmic variants of cytochrome c andor small molecule cytochrome c mimetics to activate the apoptosome in breast cancer cells.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE