Killing Breast Cancer Cells through Activation of the Apoptosome
Annual rept. 8 May 2007-7 May 2008
DUKE UNIV DURHAM NC
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Cells die in response to chemotherapeutic agents by activating a mitochondrial cell death pathway. This pathway leads to activation of proteases known as caspases through the release of cytochrome c from mitochondria. Once released, cytochrome c engages a cytoplasmic receptor known as Apaf-1, which oligomerizes and activates caspase 9. We demonstrated that breast cancer cells have apoptosomes which are hypersensitive to cytochrome c. Thus we have proposed to develop cytoplasmic variants of cytochrome c andor small molecule cytochrome c mimetics to activate the apoptosome in breast cancer cells.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research