Accession Number:

ADA499449

Title:

The Role of Cyclin E and its Lower Molecular Forms in the Oncogenesis of Ovarian Cancer and its Predictive Value in Patients with Early Stage Ovarian Tumor

Descriptive Note:

Final rept. 1 Apr 2003-31 Mar 2007

Corporate Author:

M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s):

Report Date:

2007-04-01

Pagination or Media Count:

17.0

Abstract:

The deregulation of cell cycle checkpoints, with loss of regulation at the G1S transition, has been shown to play an important role in the transformation to a malignant phenotype. Our studies have focused on cyclin E, which appears in late G1 and flanks the restriction point .We hypothesize that alterations of cyclin E in ovarian cancer cells contributes to the oncogenesis of ovarian tumors and negatively impacts outcome in patients with Stage I-III cancer. In this proposal we will i develop a comprehensive ovarian cell line model for characterization of the role of cyclin E in ovarian cancer, ii delineate the role of cyclin E and its tumor specific LMW forms in the development of malignant phenotype in vitro and in nude mice. iii establish the prognostic value of the hyperactive forms of cyclin E in patients with Stage I-III ovarian cancer and iv examine the biochemical significance of the LMW forms of cyclin E in tumor specimens. The results from our studies will provide much needed information about the molecular biology of ovarian carcinoma and may open new avenues for the development of targeted therapies.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE