Accession Number:

ADA497635

Title:

Manganese Research Health Project (MHRP)

Descriptive Note:

Final addendum rept. 1 Jan 2008-31 Jan 2009

Corporate Author:

VANDERBILT UNIV NASHVILLE TN

Personal Author(s):

• Aschner, Michael
• Fitsanakis, Vanesssa A.

Report Date:

2009-02-01

Pagination or Media Count:

146.0

Abstract:

Manganese Mn and iron are essential metals for normal growth and development that compete for and share the same transporters. Thus, during periods of low dietary iron intake, the transport and deposition of Mn in the brain are increased. Conversely, high-risk populations for Mn intoxication, namely Mn miners and welders, may benefit from iron supplementation, which may lower their central nervous system CNS Mn burden. For the first 3 years, we proposed to determine the temporal brain Mn deposition pattern using magnetic resonance imaging MRI. We have completed the imaging and atomic absorption spectroscopy AAS phases. Both iron and Mn content in six discrete brain regions have been determined, along with ascertainment of blood and plasma metal levels. Data analysis is progressing for both the brain images and R1 values from the MRI, and several manuscripts have been submitted, both addressing Mn and Fe modeling in the brain, as well as the relationship between Mn and Fe brain depositions.

Descriptors:

• *HEALTH
• *MANGANESE
• *IRON
• DEPOSITION
• MAGNETIC RESONANCE IMAGING
• NUTRITION
• CENTRAL NERVOUS SYSTEM
• WELDING
• BLOOD PLASMA
• INTOXICATION
• BRAIN
• METALS
• DATA PROCESSING
• LEVEL(QUANTITY)

Subject Categories:

• Biochemistry
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE