Accession Number:

ADA496318

Title:

Myopericarditis following Smallpox Vaccination

Descriptive Note:

Journal article

Corporate Author:

ARMY CENTER FOR HEALTH PROMOTION AND PREVENTIVE MEDICINE WASHINGTON DC ARMY MEDICAL SURVEILLANCE ACTIVITY

Report Date:

2004-04-20

Pagination or Media Count:

11.0

Abstract:

Myopericarditis has been a rare or unrecognized event after smallpox vaccinations with the New York City Board of Health strain of vaccinia virus Dryvax Wyeth Laboratories, Marietta, Pennsylvania. In this article, the authors report an attributable incidence of at least 140 clinical cases of myopericarditis per million primary smallpox vaccinations with this strain of vaccinia virus. Fifty-eight males and one female aged 2143 years with confirmed or probable acute myopericarditis were detected following vaccination of 492,730 US Armed Forces personnel from December 15, 2002, through September 30, 2003. The cases were identified through sentinel reporting to military headquarters, active surveillance using the Defense Medical Surveillance System, or reports to the Vaccine Adverse Event Reporting System. The observed incidence 16.11100,000 of myopericarditis over a 30-day observation window among 347,516 primary vaccinees was nearly 7.5-fold higher than the expected rate of 2.16100,000 95 confidence interval 1.90, 2.34 among nonvaccinated, active-duty military personnel, while the incidence of 2.07100,000 among 145,155 revaccinees was not statistically different from the expected background rate. The cases were predominantly male 5859 98.3 and White 5159 86.4, both statistically significant associations p 0.0147 and p 0.05, respectively.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE