Accession Number:

ADA495849

Title:

Identifying Breast Cancer Bone Metastasis Genes. Addendum

Descriptive Note:

Final addendum rept. 1 Aug 2007-31 Jul 2008

Corporate Author:

TEXAS UNIV AT SAN ANTONIO

Personal Author(s):

Report Date:

2008-08-01

Pagination or Media Count:

11.0

Abstract:

Bone metastasis is one of the major causes of morbidity and mortality in breast cancer BC patients. However, only a few human BC cell lines can efficiently metastasize to bone whereas most BC cell lines cannot. Recently, it was shown that systemic administration of the conditioned medium by a melanoma cell line redirected the metastatic dissemination of a weakly metastatic lung carcinoma cell line to the organ sites that were metastasized by the melanoma cell due to the formation of metastasis-permissive niches by bone marrow-derived cells BMDCs in these organ sites. The current project was proposed to test the hypothesis that factors secreted by metastasis-competent BC cells may condition bone marrow for the successful homing and skeletal remodeling of circulating BC cells. Athymic nude mice were treated with media conditioned by metastasis-competent BC cells or inoculated orthotopically with metastasis-competent BC cells and intracardiacally with non-metastatic BC cells. Non-metastatic BC cells were found in bone of mice bearing orthotopic BC tumors.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE