Identifying Breast Cancer Bone Metastasis Genes. Addendum
Final addendum rept. 1 Aug 2007-31 Jul 2008
TEXAS UNIV AT SAN ANTONIO
Pagination or Media Count:
Bone metastasis is one of the major causes of morbidity and mortality in breast cancer BC patients. However, only a few human BC cell lines can efficiently metastasize to bone whereas most BC cell lines cannot. Recently, it was shown that systemic administration of the conditioned medium by a melanoma cell line redirected the metastatic dissemination of a weakly metastatic lung carcinoma cell line to the organ sites that were metastasized by the melanoma cell due to the formation of metastasis-permissive niches by bone marrow-derived cells BMDCs in these organ sites. The current project was proposed to test the hypothesis that factors secreted by metastasis-competent BC cells may condition bone marrow for the successful homing and skeletal remodeling of circulating BC cells. Athymic nude mice were treated with media conditioned by metastasis-competent BC cells or inoculated orthotopically with metastasis-competent BC cells and intracardiacally with non-metastatic BC cells. Non-metastatic BC cells were found in bone of mice bearing orthotopic BC tumors.
- Anatomy and Physiology
- Medicine and Medical Research