Accession Number:

ADA495676

Title:

Dissecting Androgen-Dependent and Independent Signaling Pathways Using RNA Interference-Based Functional Genomics in Human Cells

Descriptive Note:

Annual rept. 1 Jun 2007-31 May 2008

Corporate Author:

DANA-FARBER CANCER INST BOSTON MA

Personal Author(s):

Report Date:

2008-06-01

Pagination or Media Count:

7.0

Abstract:

We had previously identified androgen responsive genes in LNCaP prostate cancer cells using microarray technology. I have performed a high throughput loss of function screen using RNA interference RNAi in order to identify androgen responsive genes that are critical for androgen induced proliferation. I am currently validating the candidate genes identified in my screen, and investigating whether they function in prostate tumor progression. When completed, my studies will lead to the identification and characterization of androgen regulated genes involved in prostate cancer.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE