Dissecting Androgen-Dependent and Independent Signaling Pathways Using RNA Interference-Based Functional Genomics in Human Cells
Annual rept. 1 Jun 2007-31 May 2008
DANA-FARBER CANCER INST BOSTON MA
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We had previously identified androgen responsive genes in LNCaP prostate cancer cells using microarray technology. I have performed a high throughput loss of function screen using RNA interference RNAi in order to identify androgen responsive genes that are critical for androgen induced proliferation. I am currently validating the candidate genes identified in my screen, and investigating whether they function in prostate tumor progression. When completed, my studies will lead to the identification and characterization of androgen regulated genes involved in prostate cancer.
- Medicine and Medical Research