Accession Number:

ADA495150

Title:

Topically Applied AaeIAP1 Double-Stranded RNA Kills Female Adults of Aedes aegypti

Descriptive Note:

Journal article

Corporate Author:

AGRICULTURAL RESEARCH SERVICE GAINESVILLE FL CENTER FOR MEDICAL AGRICULTURAL AND VETERINARY ENTOMOLOGY

Report Date:

2008-05-01

Pagination or Media Count:

8.0

Abstract:

Aedes aegypti L. Diptera Culicidae is the primary vector of both dengue and yellow fever. Use of insecticides is one of the primary ways to control this medically important insect pest. However, few new insecticides have been developed for mosquito control in recent years. As a part of our effort to develop new insecticides to control mosquitoes, an inhibitor of apoptosis protein 1 gene in Aedes aegypti AaeIAP1 was targeted for the development of molecular pesticides. Herein, for the first time, we report that topically applied AaeIAP1 double-stranded RNA products are able to kill female adults of Ae. aegypti. Our results indicate that critical pathways or genes could be targeted to develop molecular pesticides for the control of medically important diseases vectors.

Subject Categories:

  • Biology
  • Medicine and Medical Research
  • Ecology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE