Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer
Final Addendum 1 Sep 2007-31 Aug 2008
CALIFORNIA UNIV DAVIS
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We explored the relationship between androgen withdrawal as an event that initiates a cascade promoting the development of androgen-independent prostate cancer through neuroendocrine progression. We define the early post-castration molecular events and linked androgen-deprivation therapy to the activation of non-receptor tyrosine kinases that promote androgen-independent growth and migration. We developed an animal model to validate this hypothesis that metastasize in SCID mice. We found that deregulation through non-receptor tyrosine kinases was blocked by Src-specific inhibitor AZD0530. We found this inhibited 100 of metastasis in an animal model. The translational benefit of this study was that through a National Cancer Institute sponsored trial, the drug is being tested for hormone refractory prostate cancer.
- Medicine and Medical Research