Biotechnologies for Assessment of Toxic Hazards in Operational Environments (Utilisation des biotechnologies pour l'evaluation des risques toxiques en environnement operationnel)
NATO RESEARCH AND TECHNOLOGY ORGANIZATION NEUILLY-SUR-SEINE (FRANCE)
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Protection against toxicological threats that impair health and performance of military members requires identification of risks and methods to assess exposure. This group focused on markers of exposure for assessment of neurotoxicological threats from non-threat agents. Two model systems were examined in detail, permethrin and JP8. These represent relevant chemical mixtures that are inhalation and dermal exposure hazards with neurotoxicological potential. The group reviewed and reported research on approaches to assessing health and performance risks from these two models, ranging from neurobehavioral testing to special in vitro exposure test systems and cellular biomarkers. Interactions with physical factors e.g., heat, dust, workexercise, psychological stress, and other chemical exposures were evaluated. Research gaps in health risk communication strategies to mitigate risk and achieve optimal compliance with protective measures were also discussed. Two international Environmental and Industrial Health Hazard EIHH workshops paralleled the efforts of this panel and expanded contributions to this work. Further work in these areas is being conducted with agreements to continue sharing of information on approaches to assess neurotoxicological risks. Recommendations were made for further development of efficient processes for early predeployment consideration of potential threats, assessment and monitoring of neurochemical hazards, and lifecycle health monitoring of exposed individuals.