Regulatory T Cells and Host Anti-CML Responses
Annual rept. 1 Jun 2007-31 May 2008
CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA
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CD4CD25FoxP-3 regulatory T-cells Tregs suppress immune responses to self antigens, but also have been shown to suppress host anti-tumor responses in several human malignancies, including breast, gastrointestinal, and ovarian cancer. Identification of CML Tregs as suppressors of host anti-CML responses could have a significant impact upon CML treatment strategies. Methods are currently available to selectively suppress Tregs, and subsequently boost host anti-CML responses. We have examined the CD4CD25FoxP-3 regulatory T-cell population in the peripheral blood from healthy individuals and those with CML using flow cytometry. Our preliminary studies suggest that the Treg population is higher in those with CML mean percentage of 5.23 vs 6.94 . Furthermore, a subject with poorly controlled CML had the highest percentage of circulating Tregs 9.34 suggesting that these cells might be influencing anti-CML host responses. We are examining functional correlates of the Treg population.
- Medicine and Medical Research