Accession Number:

ADA488539

Title:

Biotic - Abiotic Interface Between they Body and the Artificial Limb

Descriptive Note:

Final rept. 15 Sep 2006-14 Sep 2007

Corporate Author:

SCIPERIO INC ORLANDO FL

Personal Author(s):

Report Date:

2008-09-29

Pagination or Media Count:

29.0

Abstract:

Intraosseous transcutaneous amputation prostheses ITAPs may be able to overcome the problems that stem from the nonuniform distribution of pressure seen in the conventional stump-socket prosthetic replacement devices. While transcutaneous devices have had limited success in amputees. By optimizing the attachment of the skin to the prosthetic, ITAPs may become clinically viable options. Our team has developed a modified titanium construct with a specially machined surface to increase the adherence of tissue as well as scaffold. A Computer Aided Biology CAB Tool was utilized to fabricate polycaprolactone PCL scaffolds with a specific three-dimensional architecture. The fabricated PCL scaffold had a tensile strength similar to skin, and when it was printed on titanium constructs, the presence of the machined surface greatly increased the its adhesion to the titanium. The antibacterial properties of titanium dioxide anatase, silver nanoparticles, and chlorhexidine diacetate mixed in either type I collagen or hyaluronic acid HA. The addition of 1 ww chlorhexidine diacetate in HA resulted in a 71 decrease in bacteria seen in non-treated HA. When the machined titanium constructs were implanted into a subcutaneous rat model, the tensile strength of the titanium-skin interface was significantly higher in machined constructs as compared with polished or acid etched constructs. These results show promise in developing a novel engineered titanium construct that promotes effective adhesion between the titanium-skin interface.

Subject Categories:

  • Medical Facilities, Equipment and Supplies
  • Inorganic Chemistry
  • Properties of Metals and Alloys
  • Computer Programming and Software

Distribution Statement:

APPROVED FOR PUBLIC RELEASE